Abstract: In order to reduce chemical fertilizers use and increase vegetable quality and yield, adopting dual quadratic rotary combinative design with three factors and five levels, we selected Brassica pekinensis, a major vegetable in HeXi Corridor of Gansu, to conduct a study concerning the relationship between the fertilization and tipburn disease control and production, and a final regression model was established. The results showed that higher N,P₂O₅ or K₂O fertilization was the major factor causing the occurence of tipburn disease increase and production drop for Brassica pekinensis. A reasonable fertilization combination should be as follows:N:420.9 kg·hm^-2~474.7 kg·hm^-2,P₂O₅:155.2 kg·hm^-2~321 kg·hm^-2,K₂O:150.0 kg·hm^-2~160.0 kg·hm^-2; the appropriate N:P₂O₅:K₂O ratio was 1:0.40~0.42:0.30~0.33.