Abstract: Crop domestication refers to the selection, modification and utilization of some available traits from wild relatives of cultivated species by artificial interventions.Crop domestication process changes plant phenotype, root architecture and root secondary metabolites, which finally changes the structure and function of the rhizosphere microorganism.We reviewed the influences of the crop domestication on the crop phenotype and root architecture, and the corresponding rhizomicrobiome change as well.We discussed the effect of domestication on rhizomicrobiome, and then focused on the relationships between domestication and symbiotic microorganisms including the arbuscular mycorrhizal fungi and rhizobium.This review would contribute more to selecting plant-beneficial microorganisms in the rhizosphere from wild plant species.