Abstract: To improve rice fertilization with Hapli-Udic Cambisol in a region of northern Liaoning Province, rice yield, nutrient accumulation, and fertilizer use efficiency in response to the combined application of nitrogen (N), phosphorus (P) and potassium (K) fertilizer were studied, which may provide a theoretical basis for balanced fertilization and fertilizer efficiency enhancement. We conducted a field experiment in 2019 and 2020 in Tieling County using five treatments: no fertilizer, NPK fertilizer 225 kg(N)·hm⁻² + 90 kg(P₂O₅)·hm⁻² + 90 kg(K₂O)·hm⁻², PK fertilizer 90 kg(P₂O₅)·hm⁻² + 90 kg(K₂O)·hm⁻², NK fertilizer 225 kg(N)·hm⁻² +90 kg(K₂O)·hm⁻², NP fertilizer 225 kg(N)·hm⁻²+ 90 kg(P₂O₅)·hm⁻² . Rice yield was the highest in the NPK treatment, 48.7%, 33.4%, 16.7% and 8.2% higher than that in the no fertilizer, PK, NK and NP fertilizer treatments, respectively. The basic soil productivity was the highest in the PK treatment and the lowest in the NPK treatment. The contents of N, P and K in grain and straw were highest in the NPK treatment, and the lowest values were observed in the no fertilizer treatment. In the two experimental years, the fertilizer use efficiency of N, P and K were 27%, 14% and 62%, respectively, by average of only 34%, which was much lower than the national rice fertilizer use efficiency of 40.2% in 2020. Therefore, although the combined application of N, P and K fertilizer may significantly increase rice yield and nutrient accumulation in this region, the amount of N and P fertilizer should be appropriately reduced in the future, while the application of organic fertilizer to improve the fertilizer use efficiency.